HCTFOOD - Activities


Sub-project: A/CZ0046/1/0008

4.1. Results
Describe predicted Results of the submitted sub-project financed by the grant. The Result indicators are meant to cover the main physical outcomes of the sub-project activities, and characteristcis of the sub-project. Please note that there will typically be more than one indicator for each Result, and often more than one Result for each activity

Predicted numerical value of Fund’s Results indicators
Indicator  Planned Realization
1.period
Realization
2. period
Realization 3. period Realization 4. period
Number of publications of results in prestigious journals(impacted, indexed or reviewed) 4 8 2 4 1
Sub-project with innovative approaches Yes Yes Yes Yes Yes
Sub-project lead by female expert
(one of leading positions)
Yes Yes Yes Yes Yes
Sub-project lead by young expert
(one of leading positions – not older than 35 y. at the moment of application)
Yes Yes Yes Yes Yes
Sub-project lead by regional entity
(applicant with seat outside of Prague or regional partner in one of leading positions )
Yes Yes Yes Yes Yes
Number of organizations supported (applicant and partners) 3 3 3 3 3
Number of R&D events supported (active participation at public seminars, conferences, exhibitions) 2 2 4 0 1
Other values - please specify
Implemented software packages 2 4 0 4 0

4.2. PurposeDescribe Purpose of submitted sub-project financed by the grant. Purpose in EEA Grants framework: direct and immediate results. For each Purpos define at least one indicator, please

Predicted numerical value of Fund’s Results indicators
Indicator  Planned Realization
1.period
Realization
2. period
Realization 3. period Realization 4. period
Number of new grants / contract of partnerships between the Czech Republic and EEA EFTA countries 2 1 1 3 0
Number of products (e.g. methods, procedures, technologies) transferred
(planned transfers)
2 4 0 1 1
Set up number of new patents, prototypes and/or industrial applications 2 0 1 1 0
Other values - please specify at least one indicator and its value



Project meetings 2 1 0 1 1
Courses 2 1 1 0 0

Results (planned/current situation), outputs:

Scientific results of the sub-project exceed any expectations risen upon project submission. In the research part of the project also the partnership was without any communication obstacles. It should be, however, mentioned that while in the Czech Republic the project enable full financing of one researcher and partial financing of three other, at the Norwegian side it was considered a small project which resulted in lower engagement.
Partnership was somewhat complicated by the fact that rules for financing of the Norwegian partners were not clearly set for them. But finally we found out how to proceed. The sustainability is guaranteed by new networking project financed by European commission.

Summary:

A) Number of publications of results in prestigious journals

1) Urban J., Vaněk J., Soukup J., Štys D.: Expertomica metabolite profiling: getting more information from LC-MS using the stochastic systems approach, Bioinformatics 25(20): 2764-2767, Oxford Journals, 2009.
(2) Levitner T, Timr Š, Stys D – Expertomica Cells: analysis of cell monolayer development, BIOINFORMATICS, 26 (2): 278-279 JAN 15 2010
(3) Stys D, Urban J, Vanek J, Cisar P - Analysis of biological time-lapse microscopic experiment form the point of view of the information theory , Micron 41: 478-483, 2010
(4) Celikovsky, Papacek, Cervantes-Herrera and Ruiz-Leon …Singular Perturbation Based Solution to Optimal Microalgal Growth Problem and Its Infinite Time Horizon Analysis –– IEEE Transactions on automatic control 55 (3), 767-772 (by mistake project HTCFOOD was not acknowledged)
(5) Blank measurement based time-alignment in LC-MS – Urban, Hrouzek, Vanek, Kopecky, Stys – submitted to chemometrics.
These include:
a) Journals cited in WOS: 6 (4 accepted), activity 2 – 5, activity 4 – 1
b) Publications in proceedings with ISBN (reviewed and indexed):
1) Preprocessing of microscopy images via Shannon's entropy, 10th International Conference "Pattern Recognition and Information Processing";2009, Minsk, ISBN 978-985-476-704-8
2) Maximisation of image contrast in label-free microscopy of living cells using information entropy computation, CYTOKINEMATICS 2009, Microscopy of Live Cells in the Post Genomics Era, The 11th symposium on live cell
imaging, Hradec Kralove, ISBN 978-80-7399-816-5
3) Expertomica metobolomics profiling: Using probabilistic system approach to gather more information from LC-MS, SIMONA 209, Liberec, CZ, ISBN 978-80-7372-543-3
4) Entropy fluxes in cell culture and its parallel implementation on GPU, SIMONA 2009, Liberec, CZ, ISBN 978-80-7372-543-3

B. Number of R&D events supported

1) D. Stys participated at ICT Europe in Lyon Nov. 25-27, 2008 (co-supported by European commission)
2) D. Stys participated at the Pollutech in Lyon Dec. 1st - 3rd 2008(co-s-upported by Czech Ministry of Industry and Trade). D Stys held lecture named „Microbiotrechnology and Nabiotechnology“ as par of the official presentation of the Czech Republic delegation
3) J. Urban and D. Stys participated at 3rd FEBS Advanced Lecture Course on Systems Biology: From Molecular Biology to Biological Function, at March 7 – 13, 2009 in Alpbach
4) J. Urban, T. Levitner, Š. Papáček, J. Vaněk and D. Štys participated at 7th meeting of Czech Structural Molecular Biologists in Nové Hrady, March 12-14th 2009,
5) J. Urban and, J. Vaněk 10th International Conference "Pattern Recognition and Information Processing"; May 19–21, 2009, Minsk, J. Urban presented lecture
6) J. Urban, T. Levitner and D. Štys participated at series of events in ISTA Klosterneuburg (Austria):
3 June : 09:30 – 15:00: Scientific Symposium “The Human Brain as the Most Powerful Computer”
3 June: 16:00 – 19:00: Panel discussion with leaders of international world class research institutions: “Institutes of Basic Research: Is There One Formula for Success?”
3 June 2009: 20:00 – 22:00: Panel discussion with leading personalities from industry “From Basic Research to Economic Value”
4 June 2009: 09:00 – 15:30: Scientific Symposium “Neurons and Machines”
7) J. Urban, T. Levitner, Š. Papáček, J. Vaněk and D. Štys participatred at SNA'10, January 18-22nd 2010 in Nové Hrady, D.Stys presented a plenary lecture, Œ. Papáček presented a lecture

C. Implemented software packages

1) Expertomica Metabolite Profiling
2) Expertomica Time-Lapse Microscopy Capture Tool
3) Expertomica Compute Entropy on GPU toolbox
4) Expertomica Hela Cells 3.03 RC
5) Expertomica DNG Reader
6) Expertomica Colony Reader
7) Expertomica Entropy Calculator
8) Expertomica Cell Marker


D. Number of new grants / contract of partnerships between the Czech Republic and EEA EFTA countries

(1)EbioInfo: Engineering approach to biological information processing (ICT Call 4, FP7-ICT-2009-4) – includes directly both Norwegina partners
(2)Aquaexcel: AQUAculture infrastructures for EXCELLence in European Fish research (FP7-INFRASTRUCTURES-2010-1) - includes directly the Nofima Food – accepted, due to be financed from July 2009
(3)IPB_Competitive: Institute of Physical Biology, University of South Bohemia international competitiveness (FP7 – REGPOT 2009-1) - Norwegian partners mentioned as training partners
(4)Physbiopot: Research potential in biophysical chemistry and physical biology (FP7 – REGPOT 2010-1) - Norwegian partners mentioned as training partners
(5)Nanocell - Live Imaging of Cellular Nanostructures ( FP7-PEOPLE-2010-ITN Marie Curie Actions) - Norwegian partners mentioned as training partners

E. Number of products (e.g. methods, procedures, technologies) transferred 

(1) Methods and know-how for the production of algal biomass
(2) Evaluation of PCA with entropy images
(3) Fermentation unit with innovative technology incubation and monitoring for biological applications
(4) Mass orbital facility for the massive cultivation of microorganisms
(5) Filtration column
(6) Separation duplicate column for biotech applications


F. Set up number of new patents, prototypes and/or industrial applications

(1) Patent: Čejka J., Kopecký J., Lukešová A., Štys D., Zelík P.: Kmen sinice Nostoc sp. Lukešová 27/97 a způsob izolace inhibitoru acetyclcholinesterasy z něho. Patent č. 299567
(2) New prototype of the micro-chamber was tested and proprietary design application is prepared

G. Project meetings

(1) First project meeting was held at January 13-14, 2009 in As
(2) Second project meeting was held at July 15-17, 2009 in Nové Hrady
(3) Third project meeting was held on March 4th, 2010 in As.

H. Courses

(1) First course was the "Multivariate data modeling in systems biology" which was held at January 12-16 2009 in As.
(2) Second course "Physical biology" was held in Nové Hrady on May 18 - 22 and June 1. -12., 2009